Authors - Kirill Kalichkin, Tatiana Gritskevich Abstract - The study is devoted to the analysis of vibration agnostics problems as a method of preventive control in the design of wheel sets of railway locomotives. The study examines vibration agnostics as a preventative control method for designing individual mechanisms and components of railway locomotive wheel sets designed for long-term, safe operation. Currently, the main issue with the mechanical drives of wheel-motor unit assemblies and motor-anchor bearing assemblies in railway locomotive wheel sets remains increased vibration during highfrequency operation. The authors analyze the prediction of potential defects using digital twins, the goal of which is to enable engineers to accurately predict solutions when similar defect signs are detected during operation of different digital twin scenarios. This enables the development of preventative measures to prevent accidents at the early stages of wheel set defect development.